Oral Antihistamine
Dstal-25
Magical Antihistamine for More than 6 Decades
Hydroxyzine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. It is used to relieve the symptoms of an allergic reaction (eg, hives, itching skin) caused by chronic Urticaria, and atopic and contact dermatoses). Hydroxyzine is also used to help control anxiety and tension caused by nervous and emotional conditions
Mechanism of Action: Hydroxyzine is a first generation antihistamine that crosses the blood/brain barrier extensively and has a high affinity for histaminic receptors into the brain, thereby producing sedativeanxiolytic effects.
Onset of action: The antihistaminic effect begins approximately after 1 hour with oral pharmaceutical forms. The sedative effect starts after 5-10 minutes with oral liquid and after 30-45 minutes with tablets.
Indications:
- Urticaria
- Dermatophytosis
- Eczema / Dermatitis
- Pruritus
Dosage:
In adults, the maximum daily dose should not exceed 100 mg per day.
For symptomatic relief in atopic pruritus: Starting dose of 25 mg at night, increasing as necessary to 25 mg three to four times daily.
For symptomatic treatment of anxiety: 50-100 mg daily in divided doses.
The dosage of Dstal-25 must be adapted to the patient’s response. For a shorter effect, half the usual dose can be given
For a shorter effect, half the usual dose can be given.
- In elderly: Use of hydroxyzine in the elderly is not recommended. However, if needed, it is advised to start with half the recommended dose due to a prolonged action. In the elderly, the maximum daily dose is 50 mg per day (see section Warnings and Precautions).
- Renal impairment: Dosage should be reduced in patients with moderate or severe renal function impairment due to decreased excretion of its metabolite cetirizine.
- Hepatic impairment: In patients with hepatic dysfunction, it is recommended to red
Composition:
Each film-coated tablet contains 25 mg of hydroxyzine hydrochloride
Presentation:
Dstal-25 is available in 10 * 10 strip Tablet pack
Adverse Reactions:
Undesirable effects are mainly related to CNS (central nervous system) depressant or paradoxical CNS stimulation effects, to anticholinergic activity, or to hypersensitivity reactions
Patient Perspective
Tips
If the cause of hives can be identified, the best treatment is to avoid the trigger or eliminate it:
Foods: Don’t eat foods that have been identified to cause your symptoms
Rubbing or scratching: Avoid harsh soaps. Frequent baths may reduce itching and scratching – beneficial because itching and scratching can make the hives feel worse
Constant pressure: Avoid tight clothing. Pressure hives can be relieved by wearing loose-fitting clothes
Temperature: If you develop hives when exposed to cold, do not swim alone in cold water and always carry an epinephrine auto-injector. Avoid exposure to cold air and use a scarf around your nose and mouth in cold weather. If you must be out in the cold, wear warm clothing
Sun exposure: Wear protective clothing; apply sunblock
Medications: Notify your physician or pharmacist immediately if you suspect that a specific medication is causing your hives.
References:
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