Oral Antifungal

Rijotra

Rijotra Star Quality Antifungal

Rijotra is technologically advanced Antifungal capsule’s with Star Quality

  • Pellets are coated with Biocatalyst material blend
  • Helps enhance the absorption of Itraconazole
  • Improves Bioavailability
  • Improves Stability compared to conventional product

Studies demonstrate that one-week treatment, using these capsules, results in a clinical response rate of over 90%

Indications

Itraconazole Capsule is indicated for the treatment of following conditions;

Dermatological/Indications:

  • Dermatomycosis – Tinea Cruris & Tinea Corporis, Tinea Manuum & Tinea Pedis
  • Pityriasis Versicolor
  • Oral Candidiasis
  • Onychomycosis, caused by Dermatophytes and/or Yeasts

Composition:

Itraconazole 100/200mg Capsules.

Presentation:

Rijotra 100 mg and 200 mg Capsules are available as hard gelatin capsules containing Itraconazole pellets in 1×10’s capsule pack respectively.

Gynecological Indications:

  • Vulvovaginal Candidiasis

Dosage

  • Tinea Cruris & Tinea Corporis, Tinea Manuum & Tinea Pedisand Tinea Versicolor – 200 mg/day for 7 days
  • Onychomycosis- Toenails: 200mg (2 capsules) once daily for 12 consecutive weeks.

Fingernails: 2 treatment pulses, each consisting of 200mg bid for 1 week. The pulses are separated by a 3-week period without Itraconazole.

  • Vulvovaginal Candidiasis- 200mg bid for 1-day.

Contraindications:

  • Itraconazole capsules are contraindicated in patients with known hypersensitivity to Itraconazole or to any of the excipients.
  • Itraconazole capsules should not be administered to patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF except for the treatment of life-threatening or other serious infections.
  • Itraconazole Capsules must not be used during pregnancy (except for life-threatening cases).

Drugs that are contraindicated with ITRACONAZOLE capsules;

  • Analgesics Methadone.
  • Anti-arrhythmics Disopyramide, Dronedarone, Quinidine.
  • Anticoagulants andAntiplatelet Drugs – Ticagrelor.
  • Antimigraine Drugs ergot alkaloids, such asdihydroergotamine, ergometrine (ergonovine), ergotamine, eletriptan.
  • Antineoplastics Irinotecan.
  • Antipsychotics.
  • Anxiolytics and Hypnotics.
  • lurasidone, Pimozide, Triazolam.
  • Antivirals Asunaprevir (boosted).
  • Calcium Channel Blockers Felodipine.
  • Cardiovascular Drugs, Ivabradine, Ranolazine
  • Diuretics Eplerenone.
  • Gastrointestinal Drugs domperidone, naloxegol.
  • Lipid Regulating Drugs lomitapide, lovastatin, simvastatin.
  • Urologic Drugs fesoterodine, in subjects with moderate to severe renal impairment, or moderate to severe hepatic impairment.
  • Solifenacin, in subjects with severe renal impairment or moderate to severehepatic impairment.
  • Miscellaneous Drugs and Other Substances colchicine, in subjects with renal or hepatic impairment, eliglustat.

There is limited information regarding cross-hypersensitivity between Itraconazole and other Azole Antifungal agents. Caution should be used in prescribing ITRACONAZOLE capsules to patients with hypersensitivity to other Azoles.

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