Topical Corticosteroid
Skivate
The Value Added Clobetasol
Each gram of Skivate Cream contains 0.5 mg of Clobetasol propionate in a white to off-white cream base consisting of cetostearyl alcohol,
isopropyl myristate, Glycerine, propylene qlycol, cetomacroqol 1000, dimethicone, purified wate
Mechanism of Action:
Clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2
Indications:
Skivate is a super-high potency corticosteroid indicated for:
Corticosteroid-Responsive Dermatoses :
Skivate is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 12 years of age and older. Treatment should be limited to 2 consecutive weeks, and the total dosage should not exceed 50 grams per week.
Moderate to Severe Plaque-Type Psoriasis:
skivate is indicated for the topical treatment of moderate to severe plaque-type psoriasis. Treatment beyond 4 consecutive weeks is not recommended. Use in
pediatric patients under 16 years of age is not recommended.
Application:
Apply a thin layer of Skivate to the affectedskin areas twice daily
Treatment should be limited to 2 consecutive weeks, and amounts greater than
50 grams per week should not be used
Composition:
Clobetasol Propionate IP 0.05 % w/w, Mehylparaben (as preservative) 0.2 % w/ w, Propylparaben (as preservative) 0.02 % w/w in a non – greasy base
Presentation:
Skivate Ointment is available in 30 gm pack
Side Effects:
May include atrophy, striae, telangiectasias, burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, hypertrichosis, perioral dermatitis, allergic contact dermatitis, secondary infection, and miliaria.
Some local adverse reactions may be irreversible.
Clobetasol propionate is not recommended in patients with acne vulgaris, rosacea or perioral dermatitis
Patient Perspective: Quick tips
Inform patients using topical corticosteroids of the following information and instructions:
- Skivate is for external use only. Avoid contact with the eyes
Use as directed. Do not use Skivate for any disorder other than that for which it was prescribed. Do not use longer than the prescribed time period. Do not use other corticosteroid containing products while using Skivate unless directed by the physician
The treated skin area should not be bandaged, otherwise covered, or wrapped so as to be occlusive unless directed by the physician
Wash hands after applying the medication
Report any signs of local or systemic adverse reactions to the physician
Inform their physicians that they are using Skivate if surgery is contemplated. If you go to another doctor for illness injury or surgery, tell the doctor you are using Skivate
Do not use Skivate on the face, underarms or groin areas
As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, contact the physician
Use no more than 50 grams per week of Skivate
Do not refrigerate
References:
www.pharmaderm.com Assessed on 2151 Sept’21
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